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UC San Diego Biologists Discover Unexpected Role for 'Zombie' Cells in Developing Brain Barriers

16 June 2026 07:35

A new study from UC San Diego reveals that senescent 'zombie' cells, typically linked to aging, are essential for building brain barriers during development. - Senescent cells appear transiently in the developing brain to help form the blood-brain barrier.

- Without these cells, barrier formation is impaired, potentially leading to neurological issues. - The findings challenge the view that senescent cells are always harmful.

- Future research may apply this to repairing brain barriers in diseases like multiple sclerosis. This discovery, published in Nature Neuroscience, highlights a beneficial role for 'zombie' cells early in life, offering new therapeutic possibilities.

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